[2022]

Kaise T, Fukui M, Sueda R, Piao W, Yamada M, Kobayashi T, Imayoshi I, Kageyama R (2022)

Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity

Genes ＆ Development DOI: 10.1101/gad.349000.121

 

[2021]

Kuriyama K, Kodama Y, Shiokawa M, Nishikawa Y, Marui S, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Matsumori T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Kageyama R , Chiba T, Seno H(2021)

Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development

J Gastroenterol DOI: 10.1007/s00535-021-01779-y. Epub

 

Zhang Y, Lahmann I, Baum K, Shimojo H, Mourikis P, Wolf J,Kageyama R , Birchmeier C (2021)

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells

Nat Commun DOI: 10.1038/s41467-021-21631-4. PMID: 33637744

 

Sueda R, Kageyama R

Oscillatory expression of Ascl1 in oligodendrogenesis

Gene Expr Patterns DOI: 10.1016/j.gep.2021.119198

 

Kaise T, Kageyama R (2021)

Hes1 oscillation frequency correlates with activation of neural stem cells

Gene Expr Patterns DOI: 10.1016/j.gep.2021.119170

 

Ohtsuka T, Kageyama R (2021)

Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain

Development 17;148(4):dev189191.doi: 10.1242/dev.189191.

 

[2020]

Matsuda M, Hayashi H, Garcia-Ojalvo J, Yoshioka-Kobayashi K, Kageyama R, Yamanaka Y, Ikeya M, Toguchida J, Alev C, Ebisuya M.(2020)

Species-specific segmentation clock periods are due to differential biochemical reaction speeds

Science DOI: 10.1126/science.aba7668

 

Anderson M　J, Magidson V, Kageyama R, Lewandoski M(2020)

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function

Elife DOI: 10.7554/eLife.55608 -1161

 

Matsumori T, Kodama Y, Takai A, Shiokawa M, Nishikawa Y, Matsumoto T, Takeda H, Marui S, Okada H, Hirano T, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Kuriyama K, Sakuma Y, Ota Y, Maruno T, Uza N, Marusawa H, Kageyama R, Chiba T, Seno H (2020)

Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma

Cancer Res DOI: 10.1158/0008-5472.CAN-20-1161

 

Yoshioka-Kobayashi K, Kageyama R (2020)

Imaging and manipulating the segmentation clock.

Cell Mol Life Sci 78(4):1221-1231.doi: 10.1007/s00018-020-03655-z.

 

Kobayashi T, Kageyama R (2020)

Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells.

FEBS J. 26;147(4):dev182204. 288(10):3082-3093. doi: 10.1111/febs.15555.

 

Kageyama R, Ochi S, Sueda R, Shimojo H (2020)

The significance of gene expression dynamics in neural stem cell regulation

Proc Jpn Acad Ser B Phys Biol Sci DOI: 10.2183/pjab.96.026

 

Matsuda M, Hayashi H, Garcia-Ojalvo J, Yoshioka-Kobayashi K, Kageyama R, Yamanaka Y, Ikeya M, Toguchida J, Alev C, Ebisuya M (2020)

Species-specific segmentation clock periods are due to differential biochemical reaction speeds

Science DOI: 10.1126/science.aba7668

 

Yahiro Y, Maeda S, Morikawa M, Koinuma D, Jokoji G, Ijuin T, Komiya S, Kageyama R, Miyazono K, Taniguchi N (2020)

BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

Bone Res DOI: 10.1038/s41413-020-00106-0

 

Yoshioka-Kobayashi K, Kageyama R (2020)

Imaging and manipulating the segmentation clock.

Cell Mol Life Sci 78(4):1221-1231.doi: 10.1007/s00018-020-03655-z.

 

Kobayashi T, Kageyama R (2020)

Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells.

FEBS J. 26;147(4):dev182204. 288(10):3082-3093. doi: 10.1111/febs.15555.

 

Fustin JM, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, Versteven M, Grunewald E, Cargill SJ, Tamai TK, Xu Y, Jabbur ML, Kojima R, Lamberti ML, Yoshioka-Kobayashi K, Whitmore D, Tammam S, Howell PL, Kageyama R, Matsuo T, Stanewsky R, Golombek DA, Johnson CH, Kakeya H, van Ooijen G, Okamura H (2020)

Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans.

Commun Biol. 4;3(1):295. doi: 10.1038/s42003-020-1031-0.

 

Fustin JM, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, Versteven M, Grunewald E, Cargill SJ, Tamai TK, Xu Y, Jabbur ML, Kojima R, Lamberti ML, Yoshioka-Kobayashi K, Whitmore D, Tammam S, Howell PL, Kageyama R, Matsuo T, Stanewsky R, Golombek DA, Johnson CH, Kakeya H, van Ooijen G, Okamura H (2020)

Methylation deficiency disrupts biological rhythms from bacteria to humans.

Commun Biol. 6;3(1):211. doi: 10.1038/s42003-020-0942-0.

 

Glaser T, Shimojo H, Ribeiro DE, Martins PPL, Beco RP, Kosinski M, Sampaio VFA, Correa-Velloso J, Oliveira-Giacomelli A, Lameu C, de Jesus Santos AP, de Souza HDN, Teng YD, Kageyama R, Ulrich H (2020)

ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research.

Mol Psychiatry. doi: 10.1038/s41380-020-0717-5.

 

Ochi S, Imaizumi Y, Shimojo H, Miyachi H, Kageyama R (2020)

Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain.

Development. 26;147(4):dev182204. doi: 10.1242/dev.182204.

 

Imayoshi I, Tabuchi S, Matsumoto M, Kitano S, Miyachi H, Kageyama R, Yamanaka A (2020)

Light-induced silencing of neural activity in Rosa26 knock-in and BAC transgenic mice conditionally expressing the microbial halorhodopsin eNpHR3.

Sci Rep. 21;10(1):3191. doi: 10.1038/s41598-020-59984-3.

 

Seymour PA, Collin CA, Egeskov-Madsen AR, Jorgensen MC, Shimojo H, Imayoshi I, de Lichtenberg KH, Kopan R, Kageyama R, Serup P (2020)

Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.

Dev Cell. 23;52(6):731-747.e8. doi: 10.1016/j.devcel.2020.01.015.

 

Bosze B, Moon MS, Kageyama R, Brown NL (2020)

Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance.

J Neurosci. 12;40(7):1501-1513. doi: 10.1523/JNEUROSCI.2327-19.2020.

 

Diaz-Cuadros M, Wagner DE, Budjan C, Hubaud A, Tarazona OA, Donelly S, Michaut A, Al Tanoury Z, Yoshioka-Kobayashi K, Niino Y,Kageyama R, Miyawaki A, Touboul J, Pourquie O (2020)

In vitro characterization of the human segmentation clock.

Nature. 580(7801):113-118. doi: 10.1038/s41586-019-1885-9.

 

Yoshioka-Kobayashi K, Matsumiya M, Niino Y, Isomura A, Kori H, Miyawaki A, Kageyama R (2020)

Coupling delay controls synchronized oscillation in the segmentation clock.

Nature. 580(7801):119-123. doi: 10.1038/s41586-019-1882-z

 

Takagi A, Isomura A, Yoshioka-Kobayashi K, Kageyama R (2020)

Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation.

Gene Expr Patterns. doi: 10.1016/j.gep.2019.119094.

 

[2019]

Shimojo H, Kageyama R (2019)

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis.

J Vis Exp. doi: 10.3791/60455.

 

Sakamoto S, Tateya T, Omori K, Kageyama R (2019)

Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.

Dev Biol. 15;460(2):164-175. doi: 10.1016/j.ydbio.2019.12.006.

 

Kobayashi T, Piao W, Takamura T, Kori H, Miyachi H, Kitano S, Iwamoto Y, Yamada M, Imayoshi I, Shioda S, Ballabio A, Kageyama R (2019)

Enhanced lysosomal degradation maintains the quiescent state of neural stem cells.

Nat Commun. doi: 10.1038/s41467-019-13203-4.

 

Tateya T, Sakamoto S, Ishidate F, Hirashima T, Imayoshi I, Kageyama R (2019)

Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea.

Development. doi: 10.1242/dev.177881.

 

Okunomiya T, Hioki H, Nishimura C, Yawata S, Imayoshi I, Kageyama R, Takahashi R, Watanabe D (2019)

Generation of a MOR-CreER knock-in mouse line to study cells and neural circuits involved in mu opioid receptor signaling.

Genesis. doi: 10.1002/dvg.23341.

 

Sueda R, Kageyama R (2019)

Regulation of active and quiescent somatic stem cells by Notch signaling.

Dev Growth Differ. doi: 10.1111/dgd.12626.

 

Vissers C, Kageyama R (2019)

Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics.

Dev Cell. doi: 10.1016/j.devcel.2019.07.028.

 

Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R (2019)

Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.

Sci Rep. doi: 10.1038/s41598-019-44698-y.

 

Sueda R, Imayoshi I, Harima Y, Kageyama R.(2019)

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain.

Genes Dev. doi: 10.1101/gad.323196.118.

 

Lahmann I, Brohl D, Zyrianova T, Isomura A, Czajkowski MT, Kapoor V, Griger J, Ruffault PL, Mademtzoglou D, Zammit PS, Wunderlich T, Spuler S, Kuhn R, Preibisch S, Wolf J, Kageyama R, Birchmeier C.(2019)

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.

Genes Dev. doi: 10.1101/gad.322818.118.

 

Nishikawa Y, Kodama Y, Shiokawa M, Matsumori T, Marui S, Kuriyama K, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Uesugi M, Kageyama R, Chiba T, Seno H.(2019)

Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.

Oncogene. doi: 10.1038/s41388-019-0718-5

 

Kageyama R, Nakajima K. (2019)

Timing and shaping mechanisms of neural development.

Neurosci Res. doi: 10.1016/j.neures.2018.12.003.

 

Ohtsuka T, Kageyama R(2019)

Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development.

Semin Cell Dev Biol. doi: 10.1016/j.semcdb.2019.01.007.